Zero-shot Human-Object Interaction detection aims to localize humans and objects in an image and recognize their interaction, even when specific verb-object pairs are unseen during training. Recent works have shown promising results using prompt learning with pretrained vision-language models such as CLIP, which align natural language prompts with visual features in a shared embedding space. However, existing approaches still fail to handle the visual complexity of interaction, including (1) intra-class visual diversity, where instances of the same verb appear in diverse poses and contexts, and (2) inter-class visual entanglement, where distinct verbs yield visually similar patterns. To address these challenges, we propose VDRP, a framework for Visual Diversity and Region-aware Prompt learning. First, we introduce a visual diversity-aware prompt learning strategy that injects group-wise visual variance into the context embedding. We further apply Gaussian perturbation to encourage the prompts to capture diverse visual variations of a verb. Second, we retrieve region-specific concepts from the human, object, and union regions. These are used to augment the diversity-aware prompt embeddings, yielding region-aware prompts that enhance verb-level discrimination. Experiments on the HICO-DET benchmark demonstrate that our method achieves state-of-the-art performance under four zero-shot evaluation settings, effectively addressing both intra-class diversity and inter-class visual entanglement. Code is available at https://github.com/mlvlab/VDRP.