Large language models have gained widespread prominence, yet their vulnerability to prompt injection and other adversarial attacks remains a critical concern. This paper argues for a security-by-design AI paradigm that proactively mitigates LLM vulnerabilities while enhancing performance. To achieve this, we introduce PromptShield, an ontology-driven framework that ensures deterministic and secure prompt interactions. It standardizes user inputs through semantic validation, eliminating ambiguity and mitigating adversarial manipulation. To assess PromptShield's security and performance capabilities, we conducted an experiment on an agent-based system to analyze cloud logs within Amazon Web Services (AWS), containing 493 distinct events related to malicious activities and anomalies. By simulating prompt injection attacks and assessing the impact of deploying PromptShield, our results demonstrate a significant improvement in model security and performance, achieving precision, recall, and F1 scores of approximately 94%. Notably, the ontology-based framework not only mitigates adversarial threats but also enhances the overall performance and reliability of the system. Furthermore, PromptShield's modular and adaptable design ensures its applicability beyond cloud security, making it a robust solution for safeguarding generative AI applications across various domains. By laying the groundwork for AI safety standards and informing future policy development, this work stimulates a crucial dialogue on the pivotal role of deterministic prompt engineering and ontology-based validation in ensuring the safe and responsible deployment of LLMs in high-stakes environments.