With the widespread adoption of Large Language Models (LLMs), prompt injection attacks have emerged as a significant security threat. Existing defense mechanisms often face critical trade-offs between effectiveness and generalizability. This highlights the urgent need for efficient prompt injection detection methods that are applicable across a wide range of LLMs. To address this challenge, we propose DMPI-PMHFE, a dual-channel feature fusion detection framework. It integrates a pretrained language model with heuristic feature engineering to detect prompt injection attacks. Specifically, the framework employs DeBERTa-v3-base as a feature extractor to transform input text into semantic vectors enriched with contextual information. In parallel, we design heuristic rules based on known attack patterns to extract explicit structural features commonly observed in attacks. Features from both channels are subsequently fused and passed through a fully connected neural network to produce the final prediction. This dual-channel approach mitigates the limitations of relying only on DeBERTa to extract features. Experimental results on diverse benchmark datasets demonstrate that DMPI-PMHFE outperforms existing methods in terms of accuracy, recall, and F1-score. Furthermore, when deployed actually, it significantly reduces attack success rates across mainstream LLMs, including GLM-4, LLaMA 3, Qwen 2.5, and GPT-4o.